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Mouse [Mus musculus]
Mouse models of stress, anxiety and depression are widely used in biological psychiatry research, and show high translatability to psychiatric disorders and treatment. Mice are sensitive to pharmacological treatments, display marked differences in behavioral phenotypes, and provide important insight into the physiological mechanisms of these disorders. A large number of mouse testing paradigms and battery test paradigms have been used to show the influence of genetic, epigenetic, and environmental factors on affective disorders, such as anxiety and depression, in addition to more complex disorders (e.g., autism, schizophrenia).
For assessment of affective phenotypes in mice, we use the open field test, plus maze, Suok test, light-dark test, place preference test, rat exposure test, social interaction, tail suspension test, forced swim test, and sucrose preference test. Pre-testing conditions have been designed to analyze genetic differences in genetically modified strains (focus of our research is on Serotonin transporter, dopamine transporter, BDNF, and NPY-ergic models). We also apply chronic mild stress, environmental enrichment, as well as acute and chronic pharmacological treatment.
Mouse Videos
- Suok test behavior (CD-1 mouse) (72 s)
- Suok test behavior (anxiogenic effects of LSD) (80 s)